实验室简介
本实验室主要从事细胞生物学研究，研究方向：干细胞生物学、肿瘤细胞生物学。聚焦细胞及分子层面，致力于细胞对环境力、化学信号感知和响应，探讨成体干细胞在软组织损伤修复中的作用机制及应用潜能，同时从肿瘤复发、转移和耐药的关键细胞---肿瘤干细胞入手，探讨肝癌、肺癌等常见恶性肿瘤发生、发展和转移的力学生物学机制及靶向干预策略。
本实验室主持承担了国家自然科学基金重点项目、面上项目、国际合作交流项目和教育部博士点基金、中科院先导专项以及重庆市自然科学基金等多项国家、省部级科研项目，已在 Cancer Letters、Theranostics、Journal of Cellular Physiology、Acta Biomaterialia等期刊发表学术论文150余篇，参编学术专著3部，申请发明专利10余件。实验室目前已培养研究生40余人，多名研究生赴美、日、德和法等国知名实验室联合培养，多名研究生的学位论文获重庆市优秀硕士/博士学位论文。
近年代表学术论文
2024年
[1] Di Ma, Rui Liang, Qing Luo, Guanbin Song*. Pressure loading regulates the stemness
of liver cancer stem cells via YAP/BMF signaling axis. Journal of Cellular
Physiology, 2024 Oct 2:e31451. Online ahead of print.
[2] Qing Li, Shan Geng, Hao Luo, Wei Wang, Yaqi Mo, Qing Luo, Lu Wang, Guanbin Song*,
Jianpeng Sheng*, Bo Xu*. Signaling pathways involved in colorectal cancer:
pathogenesis and targeted therapy. Signal Transduction and Targeted
Therapy, 2024, 9: 266.
[3] Di Ma, Qing Luo, Guanbin Song*. Matrix stiffening facilitates stemness of liver
cancer stem cells by YAP activation and BMF inhibition.
Biomaterials Advances, 2024, 163:213936.
[4] Lingli Jiang, Rui Liang, Qing Luo, Zhe Chen*, Guanbin Song*. Targeting FTO
suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression.
Biochemical Pharmacology, 2024, 226: 116375.
[5] Qian Guo, Qing Luo, Guanbin Song*. Control of muscle satellite cell function by
specific exercise-induced cytokines and their applications in muscle maintenance.n.
Journal of Cachexia, Sarcopenia and Muscle, 2024, 15:
466-476.
2023年
[1] Xiaorong Fu, Yi Zhang, Qing Luo, Yang Ju, Guanbin Song*. Targeting
mechano-microenvironment and liver cancer stem cells: a promising therapeutic
strategy for liver cancer.
Cancer Biology & Medicine, 2023, 20(11): 816-829.
[2] Yuhao Zhou, Wenjun Lv, Xiufen Peng, Yansiwei Cheng, Yun Tu, Guanbin Song*, Qing
Luo*. Simulated microgravity attenuates skin wound healing by inhibiting dermal
fibroblast migration via F-actin/YAP signaling pathway.
Journal of Cellular Physiology, 2023, 238:
2751-2764.
[3] Pu Xu, Bingyu Zhang, Qing Luo, Guanbin Song*. Mechanical stretch promotes
tenocyte migration via chromatin remodeling-mediated nuclear morphology changes.
Wound Repair and Regeneration,
2023, 31(3):410-414.