实验室承担的部分科研项目：

[1] 国家自然科学基金面上项目：Igfbp7在运动促进骨骼肌干细胞自我更新中的作用及机理，2023.01-2026.12，项目负责人：宋关斌。

[2] 基础加强计划重点基础研究项目（军工项目）：基于******技术的*******评估，2021.01-2023.05，项目负责人：宋关斌。

[3] 中国载人航天工程国际合作项目（中欧载人航天合作空间应用合作项目）：重力卸载条件下的伤口愈合与皮肤重建，2020.01-2022.12，项目负责人：宋关斌。

[4] 重庆市自然科学基金项目：力学微环境影响肝癌细胞迁移的新机制：糖代谢变化及其力信号转导，2020.07-2023.06，项目负责人：宋关斌。

[5] 重庆市教育委员会研究生导师团队项目：干细胞生物力学导师团队，2018.12-2021.12，项目负责人：宋关斌。

[6] 国家自然科学基金重点项目：力学微环境调控肝癌干细胞募集/转移的机制，2019.01-2023.12，项目负责人：宋关斌。

[7] 国家自然科学基金面上项目：力-化学耦合诱导功能性肌腱替代组织的三维构建及其修复功能评价，2018.01-2021.12，项目负责人：宋关斌。

[8] 中国科学院战略性先导科技专项子课题：空间细胞/组织培养基底牵张加载技术的生物学测试，2018.01-2020.12，项目负责人：宋关斌。

[9] 重庆市教育委员会研究生导师团队建设项目：干细胞生物力学导师团队，2019.01-2021.12，项目负责人：宋关斌。

[10] 国家自然科学基金重点项目：骨关节系统软组织力学失稳损伤及修复的机制，2016.01-2020.12，项目负责人：杨  力。

[11] 国家自然科学基金青年基金项目：力生长因子促肌腱细胞迁移的新机制：细胞核力学特性变化及其分子基础，2018.01-2020.12，项目负责人：张冰玉。

[12] 国家自然科学基金国际合作与交流项目：力-化学耦合诱导3D培养骨髓间充质干细胞向肌腱细胞定向分化研究，2015.04-2017.12，项目负责人：宋关斌。

[13] 国家自然科学基金面上项目：肿瘤干细胞分化、转移的生物力学干预及其相关分子机理研究，2013.01-2016.12，项目负责人：宋关斌。

[14] 重庆市高等学校优秀人才支持计划：生物力学对干细胞迁移、分化的调控及分子机制，2013.01-2015.12，项目负责人：宋关斌。

[15] 高等学校博士学科点专项基金: 低剪切应力促进骨髓间充质干细胞迁移的分子机制，2014.01-2015.12，项目负责人：宋关斌。

[16] 国家自然科学基金青年基金项目：力学拉伸刺激 MSCs 旁分泌对损伤肌腱细胞修复的影响及相关机理研究，2012.01-2014.12，项目负责人：罗  庆。

[17] 国家自然科学基金重点项目：MGF调控骨和韧带组织修复的力生物学基础研究，2011.01-2014.12，项目负责人：杨  力。

[18] 国家自然科学基金面上项目：机械拉伸作用调节骨髓干细胞定向分化为腱/韧带成纤维细胞的力信号途径，2008.01-2010.12，项目负责人：宋关斌。

 

近五年代表学术论文：(*通讯作者)

2024年

 

[1] Di Ma, Rui Liang, Qing Luo, Guanbin Song*. Pressure loading regulates the stemness of liver cancer stem cells via YAP/BMF signaling axis. Journal of Cellular Physiology, 2024 Oct 2:e31451. Online ahead of print.

 

[2] Qing Li, Shan Geng, Hao Luo, Wei Wang, Yaqi Mo, Qing Luo, Lu Wang, Guanbin Song*, Jianpeng Sheng*, Bo Xu*. Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy. Signal Transduction and Targeted Therapy, 2024, 9: 266.

 

[3] Di Ma, Qing Luo, Guanbin Song*. Matrix stiffening facilitates stemness of liver cancer stem cells by YAP activation and BMF inhibition. Biomaterials Advances, 2024, 163：213936.

 

[4] Lingli Jiang, Rui Liang, Qing Luo, Zhe Chen*, Guanbin Song*. Targeting FTO suppresses hepatocellular carcinoma by inhibiting ERBB3 and TUBB4A expression. Biochemical Pharmacology, 2024, 226: 116375.

 

[5] Bingyu Zhang, Zhongjie Ding; Xianxin Wen, Guanbin Song, Qing Luo*. Salinomycin and IR780-loaded upconversion nanoparticles influence biological behavior of liver cancer stem cells by persistently activating the MAPK signaling pathway. Experimental Cell Research, 2024, 434(1): 113865.

 

[6] Qian Guo, Qing Luo, Guanbin Song*. Control of muscle satellite cell function by specific exercise-induced cytokines and their applications in muscle maintenance. Journal of Cachexia, Sarcopenia and Muscle, 2024, 15: 466-476.

 

2023年

 

[7] Xiaorong Fu, Yi Zhang, Qing Luo, Yang Ju, Guanbin Song*. Targeting mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer. Cancer Biology & Medicine, 2023, 20(11): 816-829.

 

[8] Yuhao Zhou, Wenjun Lv, Xiufen Peng, Yansiwei Cheng, Yun Tu, Guanbin Song*, Qing Luo*. Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F-actin/YAP signaling pathway. Journal of Cellular Physiology, 2023, 238: 2751-2764.

 

[9] Rui Liang#, Weifeng Hong#, Yang Zhang#, Di Ma, Jinwei Li, Yisong Shi, Qing Luo, Shisuo Du*, Guanbin Song*. Deep dissection of stemness-related hierarchies in hepatocellular carcinoma. Journal of Translational Medicine, 2023, 21(1): 631.

 

[10] Rui Liang, Guanbin Song*. Matrix stiffness-driven cancer progression and the targeted therapeutic strategy. Mechanobiology in Medicine, 2023, 1: 100013.

 

[11] Wenjun Lv, Xiufen Peng, Yun Tu, Yisong Shi, Guanbin Song*, Qing Luo*. YAP inhibition alleviates simulated microgravity–induced mesenchymal stem cell senescence via targeting mitochondrial dysfunction. Antioxidants, 2023, 12(5): 990.

 

[12] Pu Xu, Bingyu Zhang, Qing Luo, Guanbin Song*. Mechanical stretch promotes tenocyte migration via chromatin remodeling-mediated nuclear morphology changes. Wound Repair and Regeneration, 2023, 31(3):410-414.

 

[13] Pu Xu, Bingyu Zhang, Bin Deng, Qing Luo, Guanbin Song*. Mechanical stretch facilitates tenomodulin expression to induce tenocyte migration via MAPK signaling pathway. Archives of Biochemistry and Biophysics, 2023, 734:109486.

 

2022年

 

[14] Yanping Tang, Yanan Fan, Qing Luo, Guanbin Song*. Pressure loading induces DNA damage in human hepatocyte line L02 cells via the ERK1/2–Dicer signaling pathway. International Journal of Molecular Sciences, 2022, 23: 5342.

 

[15] Zhe Chen, Qian Guo, Guanbin Song*, Yu Hou*. Molecular regulation of hematopoietic stem cell quiescence. Cellular and Molecular Life Sciences, 2022, 79: 218.

 

[16] Qing Li, Hao Luo, Yuanyuan Luo, Wei Zhang, Huangming Hong, Mengsheng Deng, Yang Wang, Bo Xu, Guanbin Song*, Chengxiong Xu*. Plumbagin-loaded ZIF-90 nanoparticles suppress gastric cancer progression by targeting the YAP1 signaling. Chemical Engineering Journal, 2022, 437: 135369.

 

[17] Hao Luo, Jinlu Shan, Hong Zhang, Guanbin Song, Qing Li*, Chengxiong Xu*. Targeting the epigenetic processes to enhance antitumor immunity in small cell lung cancer. Seminars in Cancer Biology, 2022, 86: 960-970.

 

[18] Hong Li, Yuchuan Sun, Qing Li, Qing Luo, Guanbin Song*. Matrix stiffness potentiates stemness of liver cancer stem cells possibly via the Yes-Associated protein signal. ACS Biomaterials Science & Engineering, 2022, 8(2): 598-609.

 

2021年

 

[19] Bin Deng, Pu Xu, Bingyu Zhang, Qing Luo, Guanbin Song*. COX2 enhances neovascularization of inflammatory tenocytes through HIF-1α/VEGFA/PDGFB pathway. Frontiers in Cell and Developmental Biology, 2021, 9: 670406.

 

[20] Zhe Chen, Dawei Huo, Lei Li, Zhilong Liu, Zhigang Li, Shuangnian Xu, Yongxiu Huang, Weiru Wu, Chengfang Zhou, Yuanyuan Liu, Mei Kuang, Feng Wu, Hui Li, Pengxu Qian, Guanbin Song, Xudong Wu, Jieping Chen*, Yu Hou*. Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis. Journal of Experimental Medicine, 2021, 218(5): e20201974.

 

[21] Jie Wang, Lin Liu, Zhongjie Ding, Qing Luo, Yang Ju, Guanbin Song*. Exogenous NAD+ postpones the senescence of bone marrow-derived mesenchymal stem cells via sirt1 signaling. Antioxidants, , 2021, 10(2): 254.

 

[22] Yuchuan Sun, Hong Li, Qiufang Chen, Qing Luo*, Guanbin Song*. The distribution of liver cancer stem cells correlates with the mechanical heterogeneity of liver cancer tissue. Histochemistry and Cell Biology, 2021, 156: 47-58.

 

[23] Chunhua Luo#, Zhongjie Ding#, Yun Tu, Jiao Tan, Qing Luo*, Guanbin Song*. Biomaterial-based platform for cancer stem cell enrichment and study. Cancer Biology & Medicine, 2021, 18(2): 458-469.

 

[24] Qiufang Chen, Bin Deng, Qing Luo, Guanbin Song*. Deep tumor-penetrated nanosystem eliminates cancer stem cell for highly efficient liver cancer therapy. Chemical Engineering Journal, 2021, 421(2): 127874.

 

[25] Bingyu Zhang, Pu Xu, Qing Luo, Guanbin Song*. Proliferation and tenogenic differentiation of bone marrow mesenchymal stem cells in a porous collagen sponge scaffold. World Journal of Stem Cells, 2021, 13(1): 115-127.

 

2020年

 

[26] Lin Liu, Yansiwei Cheng, JieWang, Zhongjie Ding, Alexander Halim, Qing Luo, Guanbin Song*. Simulated microgravity suppresses osteogenic differentiation of mesenchymal stem cells by inhibiting oxidative phosphorylation. International Journal of Molecular Sciences, 2020, 21: 9747.

 

[27] Alexander Halim, Qing Luo, Agnes Dwi Ariyanti, Guanbin Song*. Recent progress in engineering mesenchymal stem cell differentiation. Stem Cell Reviews and Reports, 2020, 16: 661-674.

 

[28] Qiuping Liu, Bin Deng, Qing Luo, Guanbin Song*. Role of mechanical microenvironment in cancer development and progression. Cancer Biology & Medicine, 2020, 17(2): 282-292.

 

[29] Ge Liu, Qing Luo, Hong Li, Qiuping Liu, Yang Ju, Guanbin Song*. Increased oxidative phosphorylation is required for stemness maintenance in liver cancer stem cells from hepatocellular carcinoma cell line HCCLM3 cells. International Journal of Molecular Sciences, 2020, 21: 5276.

 

[30] Zhe Chen, Lei Li, Weiru Wu, Zhilong Liu, Yongxiu Huang, Li Yang, Qing Luo, Jieping Chen, Yu Hou*, Guanbin Song*. Exercise protects proliferative muscle satellite cells against exhaustion via Igfbp7-Akt-mTOR axis. Theranostics, 2020, 10(14): 6448-6466.

 

[31] Qiuping Liu, Qing Luo, Bin Deng, Yang Ju, Guanbin Song*. Stiffer matrix accelerates migration of hepatocellular carcinoma cells through enhanced aerobic glycolysis via the mapk-yap signaling. Cancers, 2020, 12(2): 490.